t1/2 = 0.693/k_e, k_e = CL/Vd. Calculate elimination half-life and steady-state concentration.
One-compartment, first-order model: k = CL/Vd, t½ = ln 2/k (0.693/k), time to about 95% of steady state = 4.32 half-lives, and average steady-state concentration Css,avg = Dose/(CL x τ), which assumes 100% bioavailability (IV dosing or F = 1). Educational tool for pharmacology students and researchers; it must not be used to select or adjust doses for a patient.
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